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Zovirax Cream

Indications and Usage for Zovirax Cream

Zovirax Cream is a herpes simplex virus (HSV) nucleoside analogue DNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older.

Zovirax Cream Dosage and Administration

General

Contact Sensitization

Adverse Reactions

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice.

In five double-blind, placebo-controlled trials, 1,124 patients were treated with Zovirax Cream and 1,161 with placebo (vehicle) cream. Local application site reactions were reported by 5% of patients receiving Zovirax Cream and 4% of patients receiving placebo. The most common adverse reactions at the site of topical application were dry lips, desquamation, dryness of skin, cracked lips, burning skin, pruritus, flakiness of skin, and stinging on skin; each adverse reaction occurred in less than 1% of patients receiving Zovirax Cream and placebo. Three patients on Zovirax Cream and one patient on placebo discontinued treatment due to an adverse event.

An additional study, enrolling 22 healthy adults, was conducted to evaluate the dermal tolerance of Zovirax Cream compared with vehicle using single occluded and semi-occluded patch testing methodology. Both Zovirax Cream and placebo showed a high and cumulative irritation potential. Another study, enrolling 251 healthy adults, was conducted to evaluate the contact sensitization potential of Zovirax Cream using repeat insult patch testing methodology. Of 202 evaluable subjects, possible cutaneous sensitization reactions were observed in the same 4 (2%) subjects with both Zovirax Cream and placebo, and these reactions to both Zovirax Cream and placebo were confirmed in 3 subjects upon rechallenge. The sensitizing ingredient(s) has not been identified.

The safety profile in patients 12 to 17 years of age was similar to that observed in adults.

Postmarketing Experience

In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of acyclovir cream. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These events have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal connection to acyclovir cream.

General: Angioedema, anaphylaxis.

Drug Interactions

USE IN SPECIFIC POPULATIONS

Pregnancy

Acyclovir was not teratogenic in the mouse, rabbit, or rat at exposures greatly in excess of human exposure.

Nursing Mothers

It is not known whether topically applied acyclovir is excreted in breast milk. Systemic exposure following topical administration is minimal.

However, after oral administration of ZOVIRAX, acyclovir concentrations have been documented in breast milk in two women and ranged from 0.6 to 4.1 times the corresponding plasma levels. These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0.3 mg/kg/day. Nursing mothers who have active herpetic lesions near or on the breast should avoid nursing.

Pediatric Use

An open-label, uncontrolled trial with Zovirax Cream 5% was conducted in 113 patients aged 12 to 17 years with recurrent herpes labialis. In this trial, therapy was applied using the same dosing regimen as in adults and subjects were followed for adverse events. The safety profile was similar to that observed in adults. Safety and effectiveness in pediatric patients less than 12 years of age have not been established.

Geriatric Use

Overdosage

Overdosage by topical application of Zovirax Cream is unlikely because of minimal systemic exposure [see Clinical Pharmacology (12.3) ]. There is no information available for overdose.

Zovirax Cream Description

ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpes viruses. Zovirax Cream, 5% is a formulation for topical administration.

The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6 H - purin-6-one; it has the following structural formula:

Acyclovir is a white, crystalline powder with the molecular formula C 8 H 11 N 5 O 3 and a molecular weight of 225. The maximum solubility in water at 37°C is 2.5 mg/mL. The pKa's of acyclovir are 2.27 and 9.25.

Each gram of Zovirax Cream, 5% contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl alcohol, mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum.

Details:

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Top Assisted Living Facilities in New Jersey

November 14, 2012 by RKT

You’ll put a lot of thought into where to go next, or where your loved one will be most comfortable. Many factors are on the table for consideration when choosing a senior assisted living facility. is the care top quality? Are the facilities clean and comfortable? Are there activities to stimulate and entertain? Will I or my loved one feel at home? New Jersey offers many quality assisted living facilities. The 20 listed below, in no particular order, qualify for the list because they offer notable care, services and amenities. Each website shows photographs–many even virtual tours–to give you a feel for the community. They offer a range of services within the continuum of care and put their residents’ safety and happiness at the top of the priority list.

In no particular order, here are the “Top 20 Assisted Living Facilities in New Jersey.”

Jump to: Website Badges

Wondering how we came up with our list? Read criteria for creating our list of top assisted living facilities .

Sunrise of Old Tappan

195 Old-Tappan Road

(201) 750-1110

The small community feel only 20 minutes from the George Washington Bridge is a major draw to Sunrise of Old Tappan, located in a residential section of north eastern Bergen County. Operated by Sunrise Senior Living, Old Tappan offers a range of care options, from short stays to Alzheimer’s, memory care to assisted living and hospice. Sunrise of Old Tappan tailors their programs to the level of care their residents need. They focus on well-being, offering daily physical fitness, nutritious meals and snacks and wellness visits by a licensed on-staff nurse.

(856) 582-5292

Cardinal Village Senior Living Community is so loved by its residents, that one resident even wrote a poem of praise about it. Recently renovated, residents in both independent living and assisted living enjoy the beautiful facilities at a very reasonable cost. Cardinal Village assures no buy-in or entrance fees, long-term leases or hidden costs. Social enjoyment, safety and comfort are highly valued in this community.

From independent living to Alzheimer’s and memory care programs, the Emeritus at Cape May delivers services to residents as if they were serving their own family members. Emeritus Senior Living operates trusted senior living homes across the country. This location is hard to beat–just miles from Historic Cape May, and close to shopping, doctor’s offices, beaches and nature trails, Emeritus at Cape May could be considered a destination retirement community.

(732) 240-0043

“Care is paramount, but fun is Brandywine,” is one of their mottos, and they prove it with each day; a calendar full of stimulating and purely fun activities organized for residents of Brandywine. Their Escapades program accompanies other signature programs, including memory care, wellness, conceirge and all-day dining. In an atmosphere of pure elegance you’ll find on-site, licensed nurses available 24/7 for peace of mind and well being.

(732) 784-2400

Kensington Court Assisted Living & Adult Day Health Services was selected as “One of the Ten Best Assisted Living Communities in the Country” by the Assisted Living Federation of America. Their goal is to provide residents with abundance of care, services and amenities combined with dignity and respect. A unique feature of Kensington Court is The Club, offering daytime care with door-to-door transportation.

Cadbury at Cherry Hill provides high-quality, comprehensive services designed to meet the physical, emotional, social and spiritual needs of seniors in southern New Jersey. Without the hassle of daily chores and cooking, residents can enjoy the many amenities of Cadbury at Cherry Hill, including the heated pool, library, delicious dining, shopping at the nearby mall and orchestra performances. Cadbury includes a Nursing and Rehabilitation Center offering holistic care to residents.

(856) 829-2274

Riverview Estates was voted the Best Assisted Living of Burlington County by readers of the Burlington County Times in 2010. Located on the scenic banks of the Delaware River, nearby churches, shopping, professional offices and fine dining, Riverview Estates is a quick 20-minute drive from Philadelphia or Trenton. Qualified 24-hour skilled nursing on site means you can rest easy in this comfortable, religiously diverse community, enjoying the activities, computers and their new Snoezelen recreational therapy center.

(856) 566-2340

Although Voorhees Senior Living is located near shops and restaurants, the assisted living facility is the picture of tranquility. Nestled in a country setting nearby a pond, Voorhees Senior Living provides the personal assistance their residents need while they otherwise live as independently and actively as possible. The facility also offers Short-term Stay services for when family may be out of town or a caregiver needs a respite break.

(908) 595-6600

Arbor Glen offers the best of all worlds, situated on 28 acres in Bridgewater, surrounded by the picturesque Watchung Moutains. It’s a Friends Community, expressing the Quaker beliefs of dignity, equality and ethical business practices. The full-service senior living facility offers a list of services covered in the monthly fee, and healthcare services are available at the Holly Center, which provides a comprehensive continuum of care for people with varying medical needs.

(973) 966-5483

Many things matter to the folks at Juniper, including their residents for whom they’ve developed signature programs to keep connected, healthy and feeling cared for while at the same time independent. Juniper also keeps their team of employees well educated through In-Touch College, offering courses and training to keep the staff informed. They also care about their facilities, as they were the first assisted living facility to operate under the US Green Building Council’s Leadership in Energy and Environmental Design (LEED) program.

(908) 522-8852

A state-of-the-art assisted living community in Summit, Spring Meadows has designed a Successful Aging Programs for their residents, offering a range of programming from physical fitness to computer classes, foreign language classes, an art workshop and art history classes. The facility also offers a wide range of amenities to their residents, from community gathering spaces to spacious studio and one-bedroom apartments.

(888) 311-5231

Embracing Jewish traditions and values, the Martin & Edith Stein Assisted Living Residence offers personalized assisted living care in a warm, welcoming environment for Jewish seniors and other older adults. In the heart of the New Jersey/New York metro area, residents are able to take advantage of the culture, recreational opportunities and entertainment events the area is known for. For residents requiring care beyond daily living chores, they offer a specialized memory care neighborhood, rehabilitation and hospice care.

(732) 329-8954

A caring resource for the whole family, Buckingham Palace Adult Day Center & Home Health Care provides safety, stimulating daytime activities, nursing care, transportation, delicious food and a happy, healthy atmosphere to their members, while providing a supportive environment to caregivers. When daytime care is necessary for an elderly family member because of dementia or Alzheimer’s, frailty or other failing health issues, Buckingham Palace also offers home health care services, keeping your loved one in his or her home for as long as possible.

(973) 758-9000

CareOne at Livingston Assisted Living wants helps their residents live vibrant, independent lives, with the comfort of knowing that help is nearby if it’s needed. The facility offers a complete continuum of care, with services for residents with Alzheimer’s, dementia and other memory conditions in their Harmony Village unit. Residents also receive the benefit of rehabilitation in addition to the many social activities happening each day.

(732) 449-4444

Residents at The Arbors at Spring Lake benefit from this facility’s personal, hands-on attention. Family owned, The Arbors guarantees no entry fee, admission fee or community fee. The beautiful setting is minutes away from a local park, the center of town, many churches and the ocean, beach and boardwalk. In addition to personal assistance services, the community holds art classes, sing-alongs, exercise classes, games, activities and religious services right on campus.

(732) 851-3693

You’re treated like family at The BrookSide Assisted Living Facility, nestled in the quaint town of Freehold. Housekeeping, meals, help with daily living, medications and transportation make living at The BrookSide carefree and enjoyable. Specialized services include Alzheimer’s care, a beautifully appointed synagogue, kosher kitchen and many personalized services to make you comfortable and happy. The BrookSide Assisted Living Facility is a member of the Kaplan Senior Living Communities.

(732) 341-0880

Each apartment at The Haven at Silverwoods is both spacious and cozy, but the most impressive feature may be the emergency response system that’s connected to each living space, ready to respond to any need should it arise. Monitoring, delicious meals, weekly housekeeping, transportation assistance, social activities and scheduled visits with the registered nurse make living at The Haven at Silverwoods both worry-free and enjoyable.

(908) 707-8800

Services at the Avalon at Bridgewater are designed for security, safety, comfort and pleasure. From licensed nurses and wireless emergency response systems, to daily housekeeping and therapy, to exercise classes, libraries, a beauty salon and convenience store, the Avalon truly answers every need in an assisted living setting. For advanced memory care, Glastonbury Village with the Avalon provides the extra life skills, medical attention and safe environment necessary for comfortable living.

Winchester Gardens

333 Elmwood Avenue

Maplewood, NJ 07040

(973) 762-5050

You’ll be amazed at what you see when you look at the architecture and gardens–designed by the very same landscape architects who designed Central Park–of Winchester Gardens in Essex County. An intellectually and physically stimulating environment, Winchester Gardens is a community that can adapt to a residents’ needs as they change, from independent living to assisted living and memory care services. Providing service for nearly a century, Winchester Gardens offers amenities that are second-to-none, including a woodshop, heated indoor pool, solarium, beautiful walking trails and much more.